Our research is contributing to a recently emerged interdisciplinary area of Nanobiotechnology. Inspired by the brilliant systems in nature, research on Nanobiotechnology exploits the nanostructuring and nanofabrication of active biomacromolecules and studies the interface between biomolecules and nanotechnology. Nanobiotechnology is envisioned to assist understanding substantial new insights into how biological systems function, and in turn lead to the design of entirely new classes of micro- and nanofabricated devices and machines.In particular, our research concerns the development of hybrid nanomaterials self-assembled from proteins, nucleic acids and inorganic nanoparticles. In addition to fundamental studies on protein modifications and self-assembly methodologies, we particularly focus on their applications for nanomedicine, theranostic, biocatalysis and stimuli responsive materials.
Yu Tokura+, Sean Harvey+, Chaojian Chen, Yuzhou Wu*, David Y. W. Ng*, Tanja Weil*. Fabrication of Defined Polydopamine Nanostructures by DNA Origami-Templated Polymerization. Angew. Chem. Int. Ed. 2018, 57, 1587 –1591.
David Y. W. Ng*, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener*, Tanja Weil*. Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues. Nature Communications, 2017, 8: 1850.
Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu*, Tanja Weil, Holger Barth*, Anita Ignatius*. Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein–DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity. Adv. Healthcare Mater. 2017, 6, 1700392.
Weina Liu, Boris Naydenov, Sabyasachi Chakrabortty,Bettina Wuensch, Kristina Hübner, Sandra Ritz, Helmut Cölfen, Holger Barth, Kaloian Koynov, Haoyuan Qi, Robert Leiter, Rolf Reuter, Jörg Wrachtrup, Felix Boldt, Jonas Scheuer, Ute Kaiser, Miguel Sison, Theo Lasser, Philip Tinnefeld, Fedor Jelezko, Paul Walther, Yuzhou Wu*, Tanja Weil*, Fluorescent Nanodiamond–Gold Hybrid Particles for Multimodal Optical and Electron Microscopy Cellular Imaging, Nano Lett., 2016,DOI:10.1021/acs.nanolett.6b02456
Yu Tokura, Yanyan Jiang, Alexander Welle, Martina H Stenzel, Katarzyna Krzemien, Jens Michaelis, Christopher Barner-Kowollik, Yuzhou Wu*, Tanja Weil*, Frontispiece: Bottom‐Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom‐Transfer Radical Polymerization，Angew. Chem. Int. Ed., 2016 , 55 (19) :5692-5697.
Yuzhou Wu, Tanja Weil* et al. A Core–Shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two‐Step Release of Doxorubicin with Enhanced Anti‐Leukemia Activity. Adv. Healthcare Mater. 2012, doi: 10.1002/adhm.201200296.
Yuzhou Wu, Sabyasachi Chakrabortty, Radu A. Gropeanu, Joerg Wilhelmi, Yang Xu, Kai Shih Er, Seah Ling Kuan, Kaloian Koynov, Yinthai Chan* and Tanja Weil*. "pH-Responsive Quantum Dots via an Albumin Polymer Surface Coating" J. Am. Chem. Soc. 2010. 132(14): 5012-5014.